The first step is to convert the time in minutes to a time in hours.

60 min  =  1 hr
1  =  (1 hr)/(60 min)
20 min  =  (20 min) · 1  =  (20 min)(1 hr)/(60 min)  =  (20/60) hr  =  (1/3) hr

Then the speed v in miles per hour is given by the distance in miles divided by by the time in hours.

v  =  [22 mi] / [(1/3) hr]  =  (22 · 3) mi/hr  =  66 mi/hr